Called also antihemophilic factor (AHF) and antihemophilic globulin (AHG). Deficiency, an X-linked recessive trait, results in hemophilia a (classical hemophilia). Factor VIII is a relatively storage-labile material that participates in the intrinsic pathway of coagulation, acting as a cofactor in the activation of factor X. Called also proconvertin and serum prothrombin conversion accelerator (SPCA). Deficiency, either hereditary or acquired ( vitamin k deficiency), leads to hemorrhagic tendency. Factor VI is no longer considered in the scheme of hemostasis, and hence is assigned neither a name nor a function.įactor VII is a heat- and storage-stable material, present in serum and in plasma and participating in the extrinsic pathway of coagulation, acting with factor III to activate factor X. Called also accelerator globulin or factor and proaccelerin. Factor V is a heat- and storage-labile material, present in plasma and not in serum and is involved in the intrinsic and extrinsic pathways of coagulation, causing the cleavage of prothrombin to the active thrombin. Factor III is involved in the extrinsic pathway of coagulation, activating factor X called also tissue thromboplastin or factor.įactor IV is calcium, required in many stages of blood clotting. Factor II is a glycoprotein present in the plasma that is converted into thrombin in the common pathway of coagulation deficiency is called hypoprothrombinemia. (See table 6.)įactor I is a high-molecular-weight plasma protein that is converted to fibrin through the action of thrombin deficiency conditions are called afibrinogenemia and hypofibrinogenemia. Twelve factors, commonly designated by Roman numerals, have been described (I–V and VII–XIII VI is no longer considered to have a clotting function). Coagulation factors factors essential to normal blood clotting, whose absence, diminution, or excess may lead to abnormality of the clotting.
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